The correlation and determinants of cost-benefit analysis of measles vaccines among the medical centers providing Expanded Program on Immunization (EPI)
Abstract
Introduction: Measles is a highly contagious viral infection, vaccine-preventable diseases claim the lives of nearly 30 million people each year around the world, including 17% of children under the age of 5.
Methodology: This was a descriptive and cross-sectional investigation. Retrospective data collection was used. We looked at medical centers that provided EPI administrations.
Results: Around 8% of the youngsters in the study were found to have measles, according to the health center's records. There are an undetermined number of measles-infected children. Only 12% of those surveyed had received the measles vaccine, and the vast majority (88%) had never received the shot. According to statistical analysis, the study's r square value is r=0.35, which is considered to be an intermediate direct relationship (Wastage of vaccine and total cost). It illustrates that if there is no system of checks and balances on vaccine waste, it could have an impact on the overall cost of the vaccination. Vaccines wastage shows a positive association with Dose wastage x2= 438.8 (p-value 0.002). the breakage of vaccine vial x2 = 369.6 (p-value 0.015), expiration of vaccines x2 = 1068 (p-value 0.006), cold chain maintenance x2 = 79.99 (p-value 0.014) & inventory missing was x2 646.9 (p-value 0.004) showed statistical significance.
Conclusion: The elimination of any disease would be contributed by the parallel factors one of that includes also financial state. In less time and cost we can vaccinate the number of children and can achieve universal coverage of immunization.
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References
Saba Mazhar NS, Raza M, Akhtar B, Zahra A, Akhtar MF, Saleem A, et al. A descriptive study of Measles outbreak in Lahore, Pakistan in 2013. J Toxicol Pharmaceut Sci. 2017; 1(1):26-30.
Kaucley L, Levy P. Cost-effectiveness analysis of routine immunization and supplementary immunization activity for measles in a health district of Benin. Cost Eff Resour Alloc. 2015; 13(1):1-2.
DOI: https://doi.org/10.1186/s12962-015-0039-7
Sodha SV, Dietz V. Strengthening routine immunization systems to improve global vaccination coverage. Br Med Bull. 2015; 113(1):5-14.
DOI: https://doi.org/10.1093/bmb/ldv001
Theiss-Nyland K, Lynch M, Lines J. Assessing the availability of LLINs for continuous distribution through routine antenatal care and the Expanded Programme on Immunizations in sub-Saharan Africa. Malaria journal. 2016; 15(1):1-9.
DOI: https://doi.org/10.1186/s12936-016-1309-3
Jit M, Huyen DT, Friberg I, Van Minh H, Kiet PH, et al. Thirty years of vaccination in Vietnam: Impact and cost-effectiveness of the national Expanded Programme on Immunization. Vaccine. 2015; 33:A233-9.
DOI: https://doi.org/10.1016/j.vaccine.2014.12.017
Babigumira JB, Levin A, Burgess C, Garrison LP, Bauch CT, Braka F, et al. Assessing the cost-effectiveness of measles elimination in Uganda: local impact of a global eradication program. J Infect Dis. 2011; 204(suppl_1):S116-23.
DOI: https://doi.org/10.1093/infdis/jir132
World Health Organization. Measles vaccines: WHO position paper, April 2017–Recommendations. Vaccine. 2019; 37(2):219-22.
DOI: https://doi.org/10.1016/j.vaccine.2017.07.066
Thompson KM, Odahowski CL. Systematic review of health economic analyses of measles and rubella immunization interventions. Risk Analysis. 2016; 36(7):1297-314.
DOI: https://doi.org/10.1111/risa.12331
Goldlust S, Lee EC, Haran M, Rohani P, Bansal S. Assessing the distribution and determinants of vaccine underutilization in the United States. BioRXiv. 2017. 1:113043.
DOI: https://doi.org/10.1101/113043
Masters R, Anwar E, Collins B, Cookson R, Capewell S. Return on investment of public health interventions: A systematic review. J Epidemiol Community Health. 2017; 71(8):827-34.
DOI: https://doi.org/10.1136/jech-2016-208141
Egondi T, Oyolola M, Mutua MK, Elung’ata P. Determinants of immunization inequality among urban poor children: evidence from Nairobi’s informal settlements. Int J Equity Health. 2015; 14(1):1-5.
DOI: https://doi.org/10.1186/s12939-015-0154-2
Kazi AM. The role of mobile phone-based interventions to improve routine childhood immunisation coverage. Lancet Glob Heal. 2017; 5(4):e377-8.
DOI: https://doi.org/10.1016/S2214-109X(17)30088-8
Bekele BB, Legese T, Daniel A, Kumalo A, Yimam H, Lamaro T. Determinants of Measles Recurrent Outbreak in South West Ethiopia: an Obstacle for Implementation of Infectious Disease Eradication in the Country. EC Microbiol. 2018; 14(10):699-706.
Aderibigbe SA, Alatishe-Muhammad BW, Ameen HA, Bolarinwa OA, Salaudeen AG, Uthman MM, et al. Determinants of Missed Opportunities for Immunization among Under-five children in Ilorin Metropolis. Trop J Health Sci. 2018; 24(04).
Maharani A, Kuroda Y. Determinants of immunization status among 12-to 23-month-old children in Indonesia (2008–2013): a multilevel analysis. BMC Pub Health. 2018; 18(1):1-1.
DOI: https://doi.org/10.1186/s12889-018-5193-3
Hayman DT, Marshall JC, French NP, Carpenter TE, Roberts MG, Kiedrzynski T. Cost-benefit analyses of supplementary measles immunization in the highly immunized population of New Zealand. Vaccine. 2017; 35(37):4913-22.
DOI: https://doi.org/10.1016/j.vaccine.2017.07.077
Doshi RH, Eckhoff P, Cheng A, Hoff NA, Mukadi P, Shidi C, et al. Assessing the cost-effectiveness of different measles vaccination strategies for children in the Democratic Republic of Congo. Vaccine. 2017; 35(45):6187-94.
DOI: https://doi.org/10.1016/j.vaccine.2017.09.038
Mulders MN, Serhan F, Goodson JL, Icenogle J, Johnson BW, Rota PA. Expansion of surveillance for vaccine-preventable diseases: building on the global polio laboratory network and the global measles and rubella laboratory network platforms. J Infec Dis. 2017; 216(suppl_1):S324-30.
DOI: https://doi.org/10.1093/infdis/jix077
Loehr J. Communicating About Immunizations. Prim Care. 2020; 47:419-30.
DOI: https://doi.org/10.1016/j.pop.2020.05.010
Lam P, Williams L, Gadient S, Squires S, St Laurent M. Measles elimination in Canada. CCDR. 2015. 2;41:7.
DOI: https://doi.org/10.14745/ccdr.v41i07a03.
Byberg S, Fisker AB, Thysen SM, Rodrigues A, Enemark U, Aaby P, et al. Cost-effectiveness of providing measles vaccination to all children in Guinea-Bissau. Global Heal Action. 2017; 10(1):1329968.
DOI: https://doi.org/10.1080/16549716.2017.1329968
Ashbaugh HR, Hoff NA, Doshi RH, Alfonso VH, Gadoth A, Mukadi P, et al. Predictors of measles vaccination coverage among children 6–59 months of age in the Democratic Republic of the Congo. Vaccine. 2018; 36(4):587-93.
DOI: https://doi.org/10.1016/j.vaccine.2017.11.049
Visser O, Hautvast JL, van der Velden K, Hulscher ME. Intention to accept pertussis vaccination for cocooning: a qualitative study of the determinants. PLoS One. 2016; 11(6):e0155861.
DOI: https://doi.org/10.1371/journal.pone.0155861
Riumallo-Herl C, Chang AY, Clark S, Constenla D, Clark A, Brenzel L, et al. Poverty reduction and equity benefits of introducing or scaling up measles, rotavirus and pneumococcal vaccines in low-income and middle-income countries: a modelling study. BMJ Glob Heal. 2018; 3(2):e000613.
DOI: https://doi.org/10.1136/bmjgh-2017-000613
Farzad F, Reyer JA, Yamamoto E, Hamajima N. Socio-economic and demographic determinants of full immunization among children of 12–23 months in Afghanistan. Nagoya J Med Sci. 2017; 79(2):179.
DOI: https://doi.org/10.18999/nagjms.79.2.179
Butler R, MacDonald NE. Diagnosing the determinants of vaccine hesitancy in specific subgroups: The Guide to Tailoring Immunization Programmes (TIP). Vaccine. 2015; 33(34):4176-9.
DOI: https://doi.org/10.1016/j.vaccine.2015.04.038
Mast EE, Berg JL, Hanrahan LP, Wassell JT, Davis JP. Risk Factors for Measles in a Previously Vaccinated Population and Cost-effectiveness of Revaccination Strategies. J Am Med Assoc. 1990; 264(19):2529.
DOI: https://doi.org/10.1001/jama.1990.03450190061029
Walker D, Mosqueira NR, Penny ME, Lanata CF, Clark AD, Sanderson CFB, et al. Variation in the costs of delivering routine immunization services in Peru. Bull World Health Organ. 2004; 82:676-82.
DOI: https://doi.org/10.2471/07.045161
O’Connor P, Jankovic D, Muscat M, Ben-Mamou M, Reef S, Papania M, et al. Measles and rubella elimination in the WHO Region for Europe: progress and challenges. Clin Microbiol Infect. 2017; 23(8):504-10.
DOI: https://doi.org/10.1016/j.cmi.2017.01.003
Phillips DE, Dieleman JL, Lim SS, Shearer J. Determinants of effective vaccine coverage in low and middle-income countries: a systematic review and interpretive synthesis. BMC Healt Serv Res. 2017; 17(1):1-7.
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