Variation in COVID-19 mortality rate across populations, polymorphism in genes, and gender-associated genetic patterns

  • Kousain Kousar Department of Industrial Biotechnology, Atta ur Rahman School of Applied Biosciences, National University of Science and Technology, Islamabad, Pakistan
  • Hafiz Muhammad Imran Aziz Department of Pharmacology, Abwa Medical College, Faisalabad, Pakistan
  • Tahir Ahmad Department of Industrial Biotechnology, Atta ur Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan
  • Rameesha Abid Department of Microbiology, Quaid-i-Azam University, Islamabad, Pakistan
Keywords: COVID-19, TMPRSS2, ACE2, Gene polymorphism, Blood group susceptibility, Gender

Abstract

A severe onset of COVID-19 leads to death due to respiratory failure and ARDS is the common finding of lung histopathology in different people with different comorbidities. It can invade the nervous system leading to the manifestation of neurological symptoms and brain damage including encephalitis and stroke. Genetic polymorphism, comorbidities, and gender differences is playing a pivotal role in conferring resistance and susceptibility to COVID-19. Despite almost the same ACE2 expression profile in males and females, males have shown a high mortality rate due to higher expression of TMPRSS2 (pivotal for S protein binding) as these genes are androgen responsive. While women have shown higher expression of ADAM17, ADAM10 genes are associated with the shedding of ACE2 receptors and are estrogen-responsive, leading to low levels of membrane-bound ACE2 which is indispensable for SARS-Cov2 entry into the cell. People with blood Groups A, and AB are comparatively more susceptible to COVID-19 than people with blood group O, the reason for the O group is attributed to the presence of Anti A antibodies.

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Author Biographies

Kousain Kousar, Department of Industrial Biotechnology, Atta ur Rahman School of Applied Biosciences, National University of Science and Technology, Islamabad, Pakistan

Research Assistant

Hafiz Muhammad Imran Aziz, Department of Pharmacology, Abwa Medical College, Faisalabad, Pakistan

Assistant Professor

Tahir Ahmad, Department of Industrial Biotechnology, Atta ur Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan

Associate Professor

Rameesha Abid, Department of Microbiology, Quaid-i-Azam University, Islamabad, Pakistan

PhD Scholar

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Published
2023-02-23
How to Cite
1.
Kousar K, Aziz HM, Ahmad T, Abid R. Variation in COVID-19 mortality rate across populations, polymorphism in genes, and gender-associated genetic patterns. JSTMU [Internet]. 23Feb.2023 [cited 22Dec.2024];5(2):114-20. Available from: https://j.stmu.edu.pk/ojs/index.php/jstmu/article/view/221
Section
Review Article (without Meta-analysis)