A spectrum of severity and prevalence of malignant hyperthermia in anesthetized patients with inhalational anesthetic.
Abstract
Introduction: Malignant hyperthermia (MH) or hyperpyrexia is a pharmacogenetic syndrome of skeletal muscles caused by volatile anesthetics such as halothane and depolarized muscle relaxant suxamethonium. The prevalence of MH in Islamabad has not been explored.
Methodology: This was a retrospective study on the severity and prevalence of MH in anesthetized patients with inhalational anesthetics Clinical data from the previous years, i.e. from June 2020 to June 2021, from eight tertiary care hospitals in Islamabad was collected.
Results: Out of 40,900 patients discharged from these hospitals under general anesthesia, only 07 patients were diagnosed with MH due to anesthesia. MH is associated with gender; in our study, more incidence was observed in males than females. Of the seven patients with MH, four (57.14%) were males, and three (42.86%) were females. The prevalence rate of MH was 0.018% due to anesthesia in surgical patients which is approximately 1 per 5842 cases.
Conclusion: This research study concluded that the prevalence rate of MH in Islamabad is 0.018%. The prevalence rate for males is slightly higher than for females. According to this statement, the total number of male patients who got MH was four, and females were three out of 40900 surgical cases under general anesthesia in a specific year of duration. The prevalence of MH due to anesthesia in surgical patients treated in Islamabad hospitals is approximately 1 per 5842 cases. MH risk in males is significantly higher than in females.
Downloads
References
Tan J, Dou N, Bai G, Qiu W, Zhao Y. Research Status of Preemptive Analgesia and its Application in Clinical Anesthesia. J Res Nurs Res. 2021; 5(2).
DOI: https://doi.org/10.26689/jcnr.v5i2.1912
Pölönen P, Ruokonen E, Hippeläinen M, Pöyhönen M, Takala J. A prospective, randomized study of goal-oriented hemodynamic therapy in cardiac surgical patients. Anesth Analg. 2000; 90(5):1052-9.
DOI: https://doi.org/10.1097/00000539-200005000-00010
Roy K, Panigrahi MR, Mukhopadhyay B, Bisak S, Biswas BK. Efficacy of preoperative melatonin and ramelteon (melatonin agonist) therapy on dose requirement of propofol for induction of general anaesthesia: A comparative prospective study. Indian J Clin Anaesth. 2020; 7(1):172-6.
DOI: https://doi.org/10.18231/j.ijca.2020.030
Wenger S. Anesthesia and analgesia in rabbits and rodents. J Exot Pet Med. 2012; 21(1):7-16.
DOI: https://doi.org/10.1053/j.jepm.2011.11.010
Gami AS, Olson EJ, Shen WK, Wright RS, Ballman KV, Hodge DO, et al. Obstructive sleep apnea and the risk of sudden cardiac death: a longitudinal study of 10,701 adults. J Am Coll Cardiol. 2013; 62(7):610-6.
DOI: https://doi.org/10.1016/j.jacc.2013.04.080
Brady JE, Sun LS, Rosenberg H, Li G. Prevalence of malignant hyperthermia due to anesthesia in New York State, 2001–2005. Anesth Analg. 2009; 109(4):1162-6.
DOI: https://doi.org/10.1213/ane.0b013e3181ac1548
Hadzic A, Sala-Blanch X, Xu D. Ultrasound guidance may reduce but not eliminate complications of peripheral nerve blocks. Am Society Anesthet. 2008; 108(4):557-8.
DOI: https://doi.org/10.1097/ALN.0b013e318168efa1
Strazis KP, Fox AW. Malignant hyperthermia: a review of published cases. Anesth Analg. 1993; 77(2):297-304.
DOI: https://doi.org/10.1213/00000539-199308000-00014
Suyama H, Kawamoto M, Yuge O. Prevention and treatment of malignant hyperthermia in certified training hospitals in Japan: a questionnaire. J Anesth. 2002; 16:207-10.
DOI: https://doi.org/10.1007/s005400200026
Larach MG, Klumpner TT, Brandom BW, Vaughn MT, Belani KG, Herlich A, et al. Succinylcholine use and dantrolene availability for malignant hyperthermia treatment: database analyses and systematic review. Anesthesiology. 2019; 130(1):41-54.
DOI: https://doi.org/10.1097/ALN.0000000000002490
Larach MG, Brandom BW, Allen GC, Gronert GA, Lehman EB. Malignant hyperthermia deaths related to inadequate temperature monitoring, 2007–2012: a report from the North American malignant hyperthermia registry of the malignant hyperthermia association of the United States. Anesth Analg. 2014; 119(6):1359-66.
DOI: https://doi.org/10.1213/ANE.0000000000000421
Shafer SL, Dexter F, Brull SJ. Deadly heat: economics of continuous temperature monitoring during general anesthesia. Anesth Analg. 2014; 119(6):1235-7.
DOI: https://doi.org/10.1213/ANE.0000000000000487
Lu Z, Rosenberg H, Brady JE, Li G. Prevalence of malignant hyperthermia diagnosis in New York state ambulatory surgery center discharge records 2002 to 2011. Anesth Analg. 2016; 122(2):449-53.
DOI: https://doi.org/10.1213/ANE.0000000000001054
Ho PT, Carvalho B, Sun EC, Macario A, Riley ET. Cost-benefit analysis of maintaining a fully stocked malignant hyperthermia cart versus an initial dantrolene treatment dose for maternity units. Anesthesiology. 2018; 129(2):249-59.
DOI: https://doi.org/10.1097/ALN.0000000000002231
Wong CA. Dantrolene and malignant hyperthermia carts: do we need them on maternity units?. Anesthesiology. 2018; 129(2):225-7.
DOI: https://doi.org/10.1097/ALN.0000000000002279
Sumitani M, Uchida K, Yasunaga H, Horiguchi H, Kusakabe Y, Matsuda S, et al. Prevalence of malignant hyperthermia and relationship with anesthetics in Japan: data from the diagnosis procedure combination database. AM J Society Anaesthesiol. 2011; 114(1):84-90.
Copyright (c) 2023 Journal of Shifa Tameer-e-Millat University
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Journal of Shifa Tameer-e-Millat University (JSTMU) is the owner of all copyright to any work published in the journal. Any material printed in JSTMU may not be reproduced without the permission of the editors or publisher. The Journal accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing and/or decision in this journal. The Editorial Board makes every effort to ensure the accuracy and authenticity of material printed in the journal. However, conclusions and statements expressed are views of the authors and do not necessarily reflect the opinions of the Editorial Board or JSTMU.
Content of this journal is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
