Frequency of Vitamin D deficiency in women with polycystic ovarian syndrome.
Abstract
Introduction: Approximately 20% of women who are of reproductive age suffer from the common endocrine illness known as polycystic ovarian syndrome, or PCOS. Vitamin D insufficiency is common among PCOS-affected women. The symptoms of PCOS seem to be regulated by the vitamin D pathway. According to studies, women with PCOS had high frequencies of vitamin D insufficiency, ranging from 65.0% to 70.3%. Thus, we aimed to discover how common vitamin D deficiency was in women diagnosed with PCOS.
Methodology: This cross-sectional study was conducted at the Department of Obstetrics & Gynecology, CMH- Rawalpindi, from January to July 2022. A total of 90 women with polycystic ovarian syndrome diagnosed on Rotterdam criteria, 18 to 40 years of age, were included through a non-probability consecutive sampling technique. Pregnant female patients with chronic illnesses were excluded. After informed consent, data was collected from patients on a self-developed questionnaire. In all patients, a 3 ml blood sample was taken and sent to the institutional pathology laboratory to measure vitamin D levels.
Results: The patients' average age was 28.91 ± 4.85 years—ages 18 to 30 comprised most of the 48 patients (53.33%). The average time a person had PCOS was 3.64 ± 1.58 years. The average body mass index was 29.02 ± 2.43 kg/m2. Forty-one (45.56%) of the PCOS patients had vitamin D insufficiency.
Conclusion: As the frequency of vitamin D deficiency in women with PCOS is relatively high, we recommend that early identification through screening of the affected patients should be done.
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References
Agrawal A, Kapse A, Chaudhary A, Kalambe M. Polycystic ovarian syndrome: An overview. Australas Med J. 2021; 14(12).
DOI: 10.3390/life12121974
Dastorani M, Aghadavod E, Mirhosseini N, Foroozanfard F, ZadehModarres S, AmiriSiavashani M, Asemi, et al. The effects of vitamin D supplementation on metabolic profiles and gene expression of insulin and lipid metabolism in infertile polycystic ovary syndrome candidates for in vitro fertilization. ReprodBiolEndocrinol. 2018; 16:1-7.
DOI: https://doi.org/10.1186/s12958-018-0413-3
Miao CY, Fang XJ, Chen Y, Zhang Q. Effect of vitamin D supplementation on PCOS: a meta-analysis. ExperTherap Med. 2020; 19:2641-49.
DOI: https://doi.org/10.3892/etm.2020.8525
Jameel R, Kamran A, Jaffri SA, Sultan S. Frequency of vitamin d deficiency in women with polycystic ovarian syndrome. J SocObstetGynaecol Pak. 2019; 9(3):153-7.
Omran EF, Ramzy A, Shohaye A, Farouk N, Soliman M, Baz H, et al. Relation of serum vitamin D level in polycystic ovarian syndrome (PCOS) patients to ICSI outcome. Middle East Fertility Society J. 2020; 25:22.
DOI: https://doi.org/10.1186/s43043-020-00034-3
Muscogiuri G, Altieri B, de Angelis C, Palomba S, Pivonello R, Colao A, et al. Shedding new light on female fertility: the role of vitamin D. Rev EndocrMetabDisord. 2017; 18:273-83.
DOI: https://doi.org/10.1007/s11154-017-9407-2
Khalifa OM, ELgarhy ET, Alomda FA, Yehia MB. Assessment of serum vitamin D level in women with PCOS. Al-Azhar Int Med J. 2021; 2(11):43-8.
DOI: https://doi.org/10.21608/aimj.2021.96806.1582
Hanif QA, Qamar S, Aslam P, Omar H, Mustafa N, Masood S. Association of vitamin D deficiency with polycystic ovarian syndrome. Pak Armed Forces Med J. 2019; 69(2):241-44.
Gracelyn LJ, Pushpagiri N. Prevalence of glucose tolerance test abnormalities in women with polycystic ovarian syndrome. Int J ReprodContraceptObstet Gynecol. 2017;4(6):1740.
DOI: https://doi.org/10.18203/2320-1770.ijrcog20151215
Wang R, Mol BW. The Rotterdam criteria for polycystic ovary syndrome: evidence-based criteria?. Hum Reprod. 2017; 32(2):261-4.
DOI: https://doi.org/10.1093/humrep/dew287
Fareed A, Nauman D, Naeem A. Determine the Frequency of Vitamin D Deficiency in Patients with Polycystic Ovarian Syndrome. Pak J Med Health Sci. 2020; 25(24):22-43.
Gupta V, Mathur P, Jauhari R. Correlation of Vitamin D Levels with PCOS: A Cross-sectional Study. J Pharm Res Int. 2021; 17:41-7.
DOI: https://doi.org/10.9734/JPRI/2021/v33i59B34350
Israel N, Shamdeen M. The relation between PCOS and Vitamin D deficiency. Med J Babylon. 2019; 16(3):234.
DOI: https://doi.org/10.4103/MJBL.MJBL_37_19
Lumme J, Sebert S, Pesonen P, Piltonen T, Järvelin MR, Herzig KH, et al. Vitamin D levels in women with PCOS: a population-based study. Nutrients. 2019; 11(11):2831.
DOI: https://doi.org/10.3390/nu11112831
Asimi VZ. Evaluation of the association of vitamin D deficiency with gonadotrophins and sex hormones in obese and non-obese women with PCOS. Med Glas (Zerica) 2014; 11(1):170-6.
Hamdi RA, Abdul-Qahar ZH, Kadhum EJ, Alsaeed FA. Assessment of Serum Vitamin D Levels in Women with PCOS. Journal of the Faculty of Medicine Baghdad. 2018; 60(2):93-7.
Kensara OA. Prevalence of hypovitaminosis D and its association with hypoadiponectinemia and hyperfollistatinemia, in Saudi women with naïve PCOS. J ClinTranslEndocrinol. 2018; 12:20-5.
DOI: https://doi.org/10.1016/j.jcte.2018.04.001
Joham AE, Teede HJ, Cassar S, Stepto NK, Strauss BJ, Harrison CL, et al. Vitamin D in polycystic ovary syndrome: Relationship to obesity and insulin resistance. Molecular nutrition & food research. 2016; 60(1):110-8.
DOI: https://doi.org/10.1002/mnfr.201500259
Sulaiman EA, Dhiaa S, Merkhan MM. Overview of vitamin D role in polycystic ovarian syndrome. MMSL. 2022; 91(1):37-43.
DOI: https://doi.org/10.31482/mmsl.2021.027
Williams A, Babu JR, Wadsworth DD, Burnett D, Geetha T. The effects of vitamin D on metabolic profiles in women with PCOS: a systematic review. Hormone and Metabolic Research. 2020; 52(07):485-91.
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