Tuberculosis and scavenger receptors: Exploring their relationship.

  • Ezza Binte Tariq Research Student, Department of Biological Sciences, National University of Medical Sciences, Rawalpindi, Pakistan
  • Urooj Subhan Research Student, Department of Biochemistry, The Women's University Multan, Pakistan
  • Farah Deeba Assistant Professor, Department of Biochemistry, The Women's University Multan, Pakistan
  • Sidra Younis Associate Professor, Department of Biological Sciences, National University of Medical Sciences, Rawalpindi, Pakistan
DOI: https://doi.org/10.32593/jstmu/Vol6.Iss2.268
Keywords: Tuberculosis, Scavenger receptors, SR-B1, CD36, Single nucleotide polymorphisms

Abstract

Tuberculosis (TB) remains a significant global health concern, particularly in low- and middle-income countries. Several risk factors are associated with TB infection and its progression from infection to disease onset, including host factors, microbial factors, environmental factors, and socio-economic status. Host genetic factors play a significant role in determining susceptibility to acquiring infection, progression to active disease, and the severity of the disease. Innate immunity is essential in the initial defense, advancement, and long-term control of mycobacterial infection. Among various cell surface and intracellular receptors mediating mycobacteria uptake, scavenger receptors play a crucial role in innate immunity. Scavenger receptors are classified into 12 classes, with class B comprising SR-B1 (SCARB-1), SR-B2 (LIMP2), and SR-B3 (CD36). SR-B1 and CD36 are involved in the uptake and phagocytosis of Mycobacterium tuberculosis (Mtb). Scavenger receptors promote cytokine production and modulate cytokine production during antimycobacterial responses. The SR-B1 and CD36 genes contain various single nucleotide polymorphisms in their intronic and exonic regions. These polymorphisms may influence the expression of the genes, leading to changes in Mtb uptake and antimycobacterial response. In this current review, we have explored the importance of scavenger receptors in TB pathogenesis. Additionally, we have summarized SNPs in SR-B1 and CD36 genes and their effect on protein expression.

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Published
2024-01-08
How to Cite
1.
Tariq E, Subhan U, Deeba F, Younis S. Tuberculosis and scavenger receptors: Exploring their relationship. JSTMU [Internet]. 8Jan.2024 [cited 22Dec.2024];6(2):113-21. Available from: https://j.stmu.edu.pk/ojs/index.php/jstmu/article/view/268
Issue
Vol 6 No 2 (2023): Journal of Shifa Tameer-e-Millat University
Section
Review Article (without Meta-analysis)

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