Influence of smoking and other factors in development of cataracts in urban and rural areas. A cross-sectional study from Pakistan

  • Yasir Nawaz Department of Zoology, Faculty of Life Sciences, University of Okara, Okara, Pakistan
  • Qurat ul Ain Department of Pharmacy, University of Lahore, Lahore, Pakistan
  • Anina Qureshi Margalla College of Pharmacy, Margalla Institute of Health Sciences, Rawalpindi, Pakistan
  • Fouzia Tanvir Department of Zoology, Faculty of Life Sciences, University of Okara, Okara, Pakistan
  • Iqra Shareef
  • Mehmooda Asif Department of Molecular Biology, Faculty of Life Sciences, University of Okara, Okara, Pakistan
  • Muhammad Zaman Department of Zoology, Faculty of Life Sciences, University of Okara, Okara, Pakistan
Keywords: Smoking, Huqa, Cataract, World, Urban, Rural

Abstract

Introduction: Cataract is characterized by the clouding of the crystalline lens fibers in the eyes. Smoking has been identified as risk factor for several common and serious eye diseases, including age-related macular degeneration, glaucoma, and cataracts, all of which can lead to irreversible blindness. This study aimed to examine the relationship between tobacco smoking and non-smoking with the prevalence of cataracts in both urban and rural populations in Pakistan.

Methodology: This epidemiological study was conducted in Okara, involving approximately 2000 patients. Some participants did not provide information, resulting in a total of 1992 confirmed cases from both genders. Data was collected using a questionnaire-based form after obtaining informed consent from patients.

Results: Of the 1992 subjects, 46.13% were male and 53.87% were female. The age distribution of both groups showed a significant difference. A total of 24.60% of patients were from urban areas, while 75.40% were from rural areas, showing no significant difference. The marital status of age groups 20 to 60 and 61 to 100 showed no significant differences. For cigarette smokers aged 20 to 60, the OR / 95% CI was 10.41/2.34, while for the age group 61 to 100, it was 6.63 / 1.89, indicating a significant difference. Huqa smokers aged 20 to 60 also showed a significant difference, as did the age group 61 to 100.

Conclusion: Smoking, whether cigarettes or huqa, is strongly associated with the development of cataracts. Other factors, such as the use of pan, niswar, and marital status, also play a role.

Downloads

Download data is not yet available.

Author Biographies

Yasir Nawaz, Department of Zoology, Faculty of Life Sciences, University of Okara, Okara, Pakistan

Lecturer

Qurat ul Ain, Department of Pharmacy, University of Lahore, Lahore, Pakistan

Lecturer

Anina Qureshi, Margalla College of Pharmacy, Margalla Institute of Health Sciences, Rawalpindi, Pakistan

Senior Lecturer

Fouzia Tanvir, Department of Zoology, Faculty of Life Sciences, University of Okara, Okara, Pakistan

Assistant Professor

Mehmooda Asif, Department of Molecular Biology, Faculty of Life Sciences, University of Okara, Okara, Pakistan

MS Scholar

Muhammad Zaman, Department of Zoology, Faculty of Life Sciences, University of Okara, Okara, Pakistan

Lecturer

References

Brian G, Taylor H. Cataract blindness: challenges for the 21st century. Bull World Health Organ. 2001; 79:249-56.

World Health Organization. The World Health Report 1998: Life in the 21st century a vision for all. The World health report 1998: life in the 21st century. A vision for all 1998; 241p.

Cheng AC, Pang CP, Leung AT, Chua JK, Fan DS, Lam DS. The association between cigarette smoking and ocular diseases. Hong Kong Med J. 2000; 6(2):195.

Gupta PC, Ray CS. Smokeless tobacco and health in India and South Asia. Respirology. 2003; 8(4):419-31.

DOI: https://doi.org/10.1046/j.1440-1843.2003.00507.x.

Klein BE, Klein R, Lee KE, Meuer SM. Socioeconomic and lifestyle factors and the 10-year incidence of age-related cataracts. Am J Ophthalmol. 2003; 136(3):506-12.

DOI: https://doi.org/10.1016/s0002-9394(03)00290-3.

Buch H, Vinding T, La Cour M, Appleyard M, Jensen GB, Nielsen NV. Prevalence and causes of visual impairment and blindness among 9980 Scandinavian adults: the Copenhagen City Eye Study. Ophthalmol. 2004; 111(1):53-61.

DOI: https://doi.org/10.1016/j.ophtha.2003.05.010.

Tan JS, Wang JJ, Younan C, Cumming RG, Rochtchina E, Mitchell P. Smoking and the long-term incidence of cataract: the Blue Mountains Eye Study. Ophthalmic Epidemiol. 2008; 15(3):155-61. DOI: https://doi.org/10.1080/09286580701840362.

Arnarsson A, Jonasson F, Sasaki H, Ono M, Jonsson V, Kojima M, et al. Risk factors for nuclear lens opacification: the Reykjavik Eye Study. Development Ophthalmol. 2002; 35:12-20.

DOI: https://doi.org/10.1159/000060804.

Xu L, Cui T, Zhang S, Sun B, Zheng Y, Hu A, et al. Prevalence and risk factors of lens opacities in urban and rural Chinese in Beijing. Ophthalmol. 2006; 113(5):747-55.

DOI: https://doi.org/10.1016/j.ophtha.2006.01.026.

Wong TY, Loon SC, Saw SM. The epidemiology of age related eye diseases in Asia. Br J Ophthalmol. 2006; 90(4):506-11.

DOI: https://doi.org/10.1136/bjo.2005.083733.

Wu R, Wang JJ, Mitchell P, Lamoureux EL, Zheng Y, Rochtchina E, et al. Smoking, socioeconomic factors, and age-related cataract: The Singapore Malay Eye study. Arch Ophthalmol. 2010; 128(8):1029-35. DOI: 10.1001/archophthalmol.2010.147.

Raju P, George R, Ramesh SV, Arvind H, Baskaran M, Vijaya L. Influence of tobacco use on cataract development. Br J Ophthalmol. 2006; 90(11):1374-7.

DOI: https://doi.org/10.1136/bjo.2006.097295.

Zocchetti C, Consonni D, Bertazzi PA. Relationship between prevalence rate ratios and odds ratios in cross-sectional studies. Int J Epidemiol. 1997; 26(1):220-3.

DOI: https://doi.org/10.1093/ije/26.1.220.

Nirmalan PK, Robin AL, Katz J, Tielsch JM, Thulasiraj RD, Krishnadas R, et al. Risk factors for age-related cataract in a rural population of southern India: the Aravind Comprehensive Eye Study. Br J Ophthalmol. 2004; 88(8):989-94.

DOI: https://doi.org/10.1136/bjo.2003.038380.

Rouhiainen P, Rouhiainen H, Salonen JT. Association between low plasma vitamin E concentration and progression of early cortical lens opacities. Am J Epidemiol. 1996; 144(5):496-500.

DOI: https://doi.org/10.1093/oxfordjournals.aje.a008956.

Tsai SY, Hsu WM, Cheng CY, Liu JH, Chou P. Epidemiologic study of age-related cataracts among an elderly Chinese population in Shih-Pai, Taiwan. Ophthalmol. 2003; 110(6):1089-95.

DOI: https://doi.org/10.1016/S0161-6420(03)00243-4.

Krishnaiah S, Vilas K, Shamanna BR, Rao GN, Thomas R, Balasubramanian D. Smoking and its association with cataract: results of the Andhra Pradesh eye disease study from India. Invest Ophthalmol Vis Sci. 2005; 46(1):58-65.

DOI: https://doi.org/10.1167/iovs.04-0089.

Delcourt C, Carrière I, Delage M, Descomps B, Cristol JP, Papoz L, POLA Study Group. Associations of cataract with antioxidant enzymes and other risk factors: the French Age-Related Eye Diseases (POLA) Prospective Study. Ophthalmol. 2003; 110(12):2318-26.

DOI: https://doi.org/10.1016/s0161-6420(03)00713-9.

Leske MC, Connell AM, Wu SY, Hyman L, Schachat A. Prevalence of lens opacities in the Barbados Eye Study. Arch Ophthalmol. 1997; 115(1):105-11.

DOI: https://doi.org/10.1001/archopht.1997.01100150107018.

Barzi F, Huxley R, Jamrozik K, Lam TH, Ueshima H, Gu D, Kim HC, et al. Association of smoking and smoking cessation with major causes of mortality in the Asia Pacific Region: the Asia Pacific Cohort Studies Collaboration. Tobacco Contr. 2008; 17(3):166-72.

DOI: https://doi.org/10.1136/tc.2007.023457.

Martiniuk AL, Lee CM, Lam TH, Huxley R, Suh I, Jamrozik K, et al. The fraction of ischaemic heart disease and stroke attributable to smoking in the WHO Western Pacific and South-East Asian regions. Tobacco Contr. 2006; 15(3):181-8.

DOI: https://doi.org/10.1136/tc.2005.013284.

Huxley R, Jamrozik K, Lam TH, Barzi F, Ansary-Moghaddam A, Jiang CQ, et al. Impact of smoking and smoking cessation on lung cancer mortality in the Asia-Pacific region. Am J Epidemiol. 2007; 165(11):1280-6.

DOI: https://doi.org/10.1093/aje/kwm002.

Cackett P, Wong TY, Aung T, Saw SM, Tay WT, Rochtchina E, et al. Smoking, cardiovascular risk factors, and age-related macular degeneration in Asians: the Singapore Malay Eye Study. Am J Ophthalmol. 2008; 146(6):960-7.

DOI: https://doi.org/10.1016/j.ajo.2008.06.026

Cheung N, Lim L, Wang JJ, Islam FA, Mitchell P, Saw SM, et al. Prevalence and risk factors of retinal arteriolar emboli: the Singapore Malay Eye Study. Am J Ophthalmol. 2008; 146(4):620-4.

DOI: https://doi.org/10.1016/j.ajo.2008.05.033

Lim SL, Lim AK, Mumtaz M, Hussein E, Wan Bebakar WM, Khir AS. Prevalence, risk factors, and clinical features of thyroid-associated ophthalmopathy in multiethnic Malaysian patients with Graves' disease. Thyroid. 2008; 18(12):1297-301.

DOI: https://doi.org/10.1089/thy.2008.0044.

Klein BE, Klein R, Lee KE. Incident cataract after a five-year interval and lifestyle factors: the Beaver Dam eye study. Ophthalmic Epidemiol. 1999; 6(4):247-55.

DOI: https://doi.org/10.1076/opep.6.4.247.4190.

Navarro Esteban JJ, Gutierrez Leiva JA, Valero Caracena N, Buendia Bermejo J, Calle Puron ME, Martinez Vizcaino VJ. Prevalence and risk factors of lens opacities in the elderly in Cuenca, Spain. European J Ophthalmol. 2007; 17(1):29-37.

DOI: https://doi.org/10.1177/112067210701700105.

Giuffrè G, Dardanoni G, Lodato G. A case‐control study on risk factors for nuclear, cortical and posterior subcapsular cataract: The Casteldaccia Eye Study. Acta Ophthalmol Scandinav. 2005; 83(5):567-73.

DOI: https://doi.org/10.1111/j.1600-0420.2005.00475.x.

Foster PJ, Wong TY, Machin D, Johnson GJ, Seah SK. Risk factors for nuclear, cortical and posterior subcapsular cataracts in the Chinese population of Singapore: the Tanjong Pagar Survey. Br J Ophthalmol. 2003; 87(9):1112-20.

DOI: https://doi.org/10.1136/bjo.87.9.1112.

Cackett P, Tay WT, Aung T, Wang JJ, Shankar A, Saw SM, et al. Education, socio-economic status and age-related macular degeneration in Asians: the Singapore Malay Eye Study. Br J Ophthalmol. 2008; 92(10):1312-5.

DOI: https://doi.org/10.1136/bjo.2007.136077.

Cumming RG, Mitchell P. Alcohol, smoking, and cataracts: the Blue Mountains eye study. Arch Ophthalmol. 1997; 115(10):1296-303.

DOI: https://doi.org/10.1001/archopht.1997.01100160466015.

Ramakrishnan S, Sulochana KN, Selvaraj T, Rahim AA, Lakshmi M, Arunagiri K. Smoking of beedies and cataract: cadmium and vitamin C in the lens and blood. Br J Ophthalmol. 1995; 79(3):202-6.

DOI: https://doi.org/10.1136/bjo.79.3.202.

Pokhrel AK, Smith KR, Khalakdina A, Deuja A, Bates MN. Case-control study of indoor cooking smoke exposure and cataracts in Nepal and India. Int J Epidemiol. 2005; 34(3):702-8.

DOI: https://doi.org/10.1093/ije/dyi015.

Tan AG, Mitchell P, Flood VM, Burlutsky G, Rochtchina E, Cumming RG, et al. Antioxidant nutrient intake and the long-term incidence of age-related cataract: the Blue Mountains Eye Study. Am J Clin Nutr. 2008; 87(6):1899-905.

DOI: https://doi.org/10.1093/ajcn/87.6.1899.

Lavanya R, Wong TY, Aung T, Tan DT, Saw SM, Tay WT, et al. Prevalence of cataract surgery and post-surgical visual outcomes in an urban Asian population: the Singapore Malay Eye Study. Br J Ophthalmol. 2009; 93(3):299-304.

DOI: https://doi.org/10.1136/bjo.2008.148650.

Published
2024-08-02
How to Cite
1.
Nawaz Y, Ain Q, Qureshi A, Tanvir F, Shareef I, Asif M, Zaman M. Influence of smoking and other factors in development of cataracts in urban and rural areas. A cross-sectional study from Pakistan. JSTMU [Internet]. 2Aug.2024 [cited 21Nov.2024];7(1):6-3. Available from: https://j.stmu.edu.pk/ojs/index.php/jstmu/article/view/270