Prevalence of antibiotic resistance in patients with urinary tract infections

Fatima Khurshid; Hina Aziz; Mohammad Zain; Faraz Arshad; Misbah Mughal; Tayyaba Ghazanfar

doi:10.32593/jstmu/Vol7.Iss1.298

Fatima Khurshid Department of Medicine, Mohi-ud-Din Teaching Hospital, Mirpur AJK, Pakistan
Hina Aziz Department of Medicine, Fatima Jinnah Medical University, Lahore, Pakistan
Mohammad Zain Department of Health Card Office, State Life, Islamabad, Pakistan
Faraz Arshad Department of Medicine, Shaikh Zayed Hospital, Lahore, Pakistan
Misbah Mughal Department of Biosciences, Islamic International University, Islamabad, Pakistan
Tayyaba Ghazanfar Health Services, Islamabad, Pakistan

DOI: https://doi.org/10.32593/jstmu/Vol7.Iss1.298

Keywords: Antibiotic resistance, Antibiotic Stewardship., Klebsiella Pneumoniae, Antimicrobials, Urinary tract infection

Abstract

Introduction: Antibiotic resistance is a significant threat to the effective treatment of urinary tract infections (UTIs). The frequency of antibiotic-resistant UTIs is becoming increasingly concerning due to the possible consequences for patient health and healthcare expenses.

Methodology: A retrospective research at DHQ Hospital Mirpur AJK examined 225 patients with febrile UTIs from Dec 2023 to Feb 2024. Urine samples were collected and antibiotic testing were performed in accordance with Clinical and Laboratory Standards Institute standards.

Results: The study revealed alarming antibiotic resistance rates in urine isolates. Klebsiella spp. showed high resistance to Ceftriaxone (54%), Colistin (57%), and Cefuroxime (86%). Staphylococcus aureus exhibited significant resistance to Erythromycin (64%) and Doxycycline (81%). Escherichia coli displayed resistance to Ceftriaxone (23%) and Amoxicillin (25%). Notably, all species were susceptible to Vancomycin, with no observed resistance.

Conclusion: This study demonstrates significant antibiotic resistance among bacterial species that cause urinary tract infections (UTIs), with Klebsiella pneumoniae showing the highest resistance rates. Effective antibiotic stewardship are urgently required to address this issue and enhance UTI care.

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Author Biographies

Fatima Khurshid, Department of Medicine, Mohi-ud-Din Teaching Hospital, Mirpur AJK, Pakistan

Medical Doctor

Hina Aziz, Department of Medicine, Fatima Jinnah Medical University, Lahore, Pakistan

Medical Graduate

Mohammad Zain, Department of Health Card Office, State Life, Islamabad, Pakistan

District Medical Officer

Faraz Arshad, Department of Medicine, Shaikh Zayed Hospital, Lahore, Pakistan

House Officer

Misbah Mughal, Department of Biosciences, Islamic International University, Islamabad, Pakistan

Lecturer

Tayyaba Ghazanfar, Health Services, Islamabad, Pakistan

Executive Territorial Business Head-Supply Chain

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