Dengue - A comprehensive review detailing regional prevalence, clinical aspects and novel treatment

Maryam Saqib; Ahmed Munawar; Sarha .; Hassan Hameed Malik; Hussain Hameed Malik

doi:10.32593/jstmu/Vol7.Iss2.356

Maryam Saqib Department of Pharmacology, King Edward Medical University, Lahore, Pakistan
Ahmed Munawar Aziz Fatima Medical and Dental College, Faisalabad, Pakistan
Sarha . Aziz Fatima Medical and Dental College, Faisalabad, Pakistan
Hassan Hameed Malik Combined Military Hospital, Abbottabad, Pakistan
Hussain Hameed Malik Shah Faisal Hospital, Haripur, Pakistan

DOI: https://doi.org/10.32593/jstmu/Vol7.Iss2.356

Keywords: Dengue shock syndrome, Dengue virus (DENV), NS Protein

Abstract

Dengue fever poses a grave health risk to the majority of the urban population in humid and temperate regions. The virus has four serologic variants where secondary infection by heterozygous serotype can lead to antibody-dependent enhancement, also a limitation of the proposed vaccine Dengvaxia. Classically presented as an acute self-limiting febrile illness its diagnosis is concluded by reverse transcription polymerase chain reaction and NS1 antigens as gold standard. Current treatment modalities are limited to pain and fluid management. The targeted antiviral therapies for viral genome, fusion and entry, replication, and halting immunological cascade are still under clinical investigations and population trials. This article aims to detail the pathognomic pathway, clinical picture, and regional burden of the dengue virus to narrow down and associate it with modern treatment modalities. The search engines used were PubMed, Google Scholar, and Scopus, and the data was compiled in three months.

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Author Biographies

Maryam Saqib, Department of Pharmacology, King Edward Medical University, Lahore, Pakistan

Assistant Professor, Department of Pharmacology, King Edward Medical University, Lahore, Pakistan

Ahmed Munawar, Aziz Fatima Medical and Dental College, Faisalabad, Pakistan

Department of Pharmacology, Aziz Fatima Medical and Dental College, Faisalabad, Pakistan

Sarha ., Aziz Fatima Medical and Dental College, Faisalabad, Pakistan

Medical Officer, Department of Pharmacology, Aziz Fatima Medical and Dental College, Faisalabad, Pakistan

Hassan Hameed Malik, Combined Military Hospital, Abbottabad, Pakistan

Medical Officer, Department of Radiology, Combined Military Hospital, Abbottabad, Pakistan

Hussain Hameed Malik, Shah Faisal Hospital, Haripur, Pakistan

Medical Officer, Department of Pediatrics, Shah Faisal Hospital, Haripur, Pakistan

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