Frequency of cesarean section in term pregnancies induced with prostin-E2: A descriptive case series from a tertiary care hospital in Pakistan

  • Arooj Fatima Type D Hospital Khanpur, Khyber Pakhtunkhwa, Pakistan
  • Hafiz Muhammad Imran Aziz Faisalabad Medical University, Faisalabad, Pakistan
  • Mamoona Dar University of Sargodha, Sargodha, Pakistan
  • Rifat Riaz Layllpur Institute of Advanced Studies, Faisalabad, Pakistan
  • Faiza Habib Combined Military Hospital and Medical College, Lahore, Pakistan
Keywords: Pregnancy, Labor induction, Prostein-E2, Cesarean section

Abstract

Introduction: Since the 1960s, prostaglandins have been used extensively in clinical practice to induce labor; nevertheless, gastrointestinal symptoms, such as nausea, vomiting, and diarrhea, as well as uterine hyperstimulation and fever, have been documented as adverse effects. Numerous prostaglandin preparations have been administered orally, intramuscularly, intravenously, and locally (intravaginal and intracervical).

Methodology: From September 1, 2019, to February 1, 2020, the Department of Obstetrics and Gynecology at Ayub Teaching Hospital in Abbottabad undertook a descriptive case series to ascertain the frequency of cesarean sections among patients induced with the pill Prostein-E2 at term. The study comprised 155 pregnant women who were having labor induction. Dinoprostone tablets were given to each patient; three milligrams were injected enters the fornix of the posterior vagina. A third 3 mg tablet was administered when the cervix was favorable (Bishop score ± 8) after two more vaginal exams that were separated by six hours.

Results: The study's age range was 18–40 years old, with a mean gestational age of 27.903 ± 2.61 years of 38.071 ± 0.73 weeks, a mean number of doses of 1.335 ± 0.47, a mean parity of 1.419 ± 1.16, and a mean weight of 65.664 ± 4.77 Kg. Cesarean section was seen in 20% of patients.

Conclusion: Therefore, induction of labor in the presence of an immature cervix is linked to failure to progress labor, induction failure, and cesarean section risk.

Downloads

Download data is not yet available.

Author Biographies

Arooj Fatima, Type D Hospital Khanpur, Khyber Pakhtunkhwa, Pakistan

Women Medical Officer, Type D Hospital Khanpur, Khyber Pakhtunkhwa, Pakistan

Hafiz Muhammad Imran Aziz, Faisalabad Medical University, Faisalabad, Pakistan

Assistant Professor, Department of Pharmacology, Faisalabad Medical University, Faisalabad, Pakistan

Mamoona Dar, University of Sargodha, Sargodha, Pakistan

Lecturer, College of Pharmacy, University of Sargodha, Sargodha, Pakistan

Rifat Riaz, Layllpur Institute of Advanced Studies, Faisalabad, Pakistan

Lecturer, College of Pharmacy, Layllpur Institute of Advanced Studies, Faisalabad, Pakistan

Faiza Habib, Combined Military Hospital and Medical College, Lahore, Pakistan

Assistant Professor, Department of Physiology, Combined Military Hospital and Medical College, Lahore, Pakistan

References

Kreft M, Krähenmann F, Roos M, Kurmanavicius J, Zimmermann R, Ochsenbein-Kölble N. Maternal and neonatal outcome of labour induction at term comparing two regimens of misoprostol. J Perinat Med. 2014; 42(5):603-9.

DOI: https://doi.org/10.1515/jpm-2013-0215.

Ibishi VA, Isjanovska RD. Prelabour rupture of membranes: mode of delivery and outcome. Open Access Maced J Med Sci. 2015; 3(2):237-40.

DOI: https://doi.org/10.3889/oamjms.2015.037.

Thomas J, Fairclough A, Kavanagh J, Kelly AJ. Vaginal prostaglandin (PGE2 and PGF2a) for induction of labour at term. Cochrane Database Syst Rev. 2014; (6):CD003101

DOI: https://doi.org/10.1002/14651858.CD003101.pub3.

Dülger Ö, Sik BA, Aba YA. A comparative randomized study on the effect of vaginally administered glyceryl trinitrate placebo on cervical ripening prior to induction of labor in overdue pregnancies. Indian J Pharmacol. 2018; 50:260-5.

DOI: https://doi.org/10.4103/ijp.IJP_182_18.

Knight HE, Cromwell DA, Gurol-Urganci I, Harron K, van der Meulen JH, Smith GCS. Perinatal mortality associated with induction of labour versus expectant management in nulliparous women aged 35 years or over: an English national cohort study. PLoS Med. 2017; 14(11):e1002425.

DOI: https://doi.org/10.1371/journal.pmed.1002425.

American College of Obstetricians and Gynecologists' Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 205: Vaginal Birth After Cesarean Delivery. Obstet Gynecol. 2019 Feb; 133(2):e110e127.

DOI: https://doi.org/10.1097/AOG.0000000000003078

Clapp MA, Barth WH. The Future of Cesarean Delivery Rates in the United States. Clin Obstet Gynecol. 2017; 60(4):829-839.

DOI: https://doi.org/10.1097/GRF.0000000000000325.

Kasagi Y, Okutani R, Oda Y. Specialized operating room for cesarean section in the perinatal care unit: a review of the opening process and operating room management. J Anesth. 2015; 29(1):149-51.

DOI: https://doi.org/10.1007/s00540-014-1861-3.

Wilson RD, Caughey AB, Wood SL, Macones GA, Wrench IJ, Huang J, et al. Guidelines for Antenatal and Preoperative care in Cesarean Delivery: Enhanced Recovery After Surgery Society Recommendations (Part 1). Am J Obstet Gynecol. 2018; 219(6):523.e1-523.e15.

DOI: https://doi.org/10.1016/j.ajog.2018.09.015.

Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 199: Use of Prophylactic Antibiotics in Labor and Delivery. Obstet Gynecol. 2018; 132(3):e103-e119.

DOI: https://doi.org/10.1097/AOG.0000000000002833.

Smid MC, Dotters-Katz SK, Silver RM, Kuller JA. Body Mass Index 50 kg/m2 and Beyond: Perioperative Care of Pregnant Women With Superobesity Undergoing Cesarean Delivery. Obstet Gynecol Surv. 2017; 72(8):500-510.

DOI: https://doi.org/10.1097/OGX.0000000000000469.

Tita ATN, Boggess K, Saade G. Adjunctive Azithromycin Prophylaxis for Cesarean Delivery. N Engl J Med. 2017; 376(2):182.

DOI: https://doi.org/10.1056/NEJMc1614626.

Haas DM, Morgan S, Contreras K, Enders S. Vaginal preparation with antiseptic solution before cesarean section for preventing postoperative infections. Cochrane Database Syst Rev. 2018; 7:CD007892.

DOI: https://doi.org/10.1002/14651858.CD007892.pub6.

Walton RB, Shnaekel KL, Ounpraseuth ST, Napolitano PG, Magann EF. High transverse skin incisions may reduce wound complications in obese women having cesarean sections: a pilot study. J Matern Fetal Neonatal Med. 2019; 32(5):781-785.

DOI: https://doi.org/10.1080/14767058.2017.1391780.

Fogarty M, Osborn DA, Askie L, Seidler AL, Hunter K, Lui K, et al. Delayed vs early umbilical cord clamping for preterm infants: a systematic review and meta-analysis. Am J Obstet Gynecol. 2018; 218(1):1-18.

DOI: https://doi.org/10.1016/j.ajog.2017.10.231.

Cavallin F, Galeazzo B, Loretelli V, Madella S, Pizzolato M, Visentin S, et al. Delayed Cord Clamping versus Early Cord Clamping in Elective Cesarean Section: A Randomized Controlled Trial. Neonatology. 2019; 116(3):252-259.

DOI: https://doi.org/10.1159/000500325.

Stegwee SI, Jordans I, van der Voet LF, van de Ven PM, Ket J, Lambalk CB, et al. Uterine cesarean closure techniques affect ultrasound findings and maternal outcomes: a systematic review and meta-analysis. BJOG. 2018; 125(9):1097-1108

DOI: https://doi.org/10.1111/1471-0528.15048.

Roberge S, Demers S, Girard M, Vikhareva O, Markey S, Chaillet N, et al. Closure methods for laparotomy incisions for preventing incisional hernias and other wound complications. Cochrane Database Syst Rev. 2017; 11:CD005661.

DOI: https://doi.org/10.1002/14651858.CD005661.pub2.

Indraccolo U, Pace M, Corona G, Bonito M, Indraccolo SR, Di Iorio R. Cesarean section in the absence of labor and risk of respiratory complications in newborns: a case-control study. J Matern Fetal Neonatal Med. 2019; 32(7):1160-1166.

DOI: https://doi.org/10.1080/14767058.2017.1401999.

Gross B, Rusin L, Kiesewetter J, Zottmann JM, Fischer MR, et al. Crew resource management training in healthcare: a systematic review of intervention design, training conditions and evaluation. BMJ Open. 2019; 9(2):e025247.

DOI: https://doi.org/10.1136/bmjopen-2018-025247.

Greer JA, Haischer-Rollo G, Delorey D, Kiser R, Sayles T, Bailey J, et al. In-situ Interprofessional Perinatal Drills: The Impact of a Structured Debrief on Maximizing Training While Sensing Patient Safety Threats. Cureus. 2019; 11(2):e4096.

DOI: https://doi.org/10.7759/cureus.4096.

Published
2024-12-31
How to Cite
1.
Fatima A, Aziz H, Dar M, Riaz R, Habib F. Frequency of cesarean section in term pregnancies induced with prostin-E2: A descriptive case series from a tertiary care hospital in Pakistan. JSTMU [Internet]. 31Dec.2024 [cited 18Nov.2025];7(2):191 -195. Available from: https://j.stmu.edu.pk/ojs/index.php/jstmu/article/view/367