Treatment of unexplained thin endometrium with autologous platelet-rich plasma in a frozen embryo transfer cycle

  • Sara Mahmood Salma Kafeel Medical Services, Blue Area, Islamabad, Pakistan
  • Salma Kafeel Salma Kafeel Medical Services, Blue Area, Islamabad, Pakistan
  • Riffat Bibi Salma Kafeel Medical Services, Blue Area, Islamabad, Pakistan
  • Naveed Iqbal Salma Kafeel Medical Services, Blue Area, Islamabad, Pakistan
Keywords: Frozen Embryo Transfer, platelet-rich plasma, thin endometrium, endometrial thickness

Abstract

Inadequate endometrial proliferation is a known cause of implantation failure in assisted reproductive technology cycles. It is generally agreed that >9 mm endometrial thickness is associated with higher implantation. Several strategies have been explored to enhance endometrial proliferation. However, the results are either poor, inconsistent or subject to safety concerns. A 34-year old woman presented with unexplained thin endometrium in successive frozen embryo transfer (FET) cycles. Autologous platelet-rich plasma (PRP) was infused in the uterine cavity on day 10 of second FET cycle enhancing endometrial thickness, which post-PRP infusion measured 10.9 mm. Blastocyst-stage embryos were transferred resulting in a successful pregnancy. Autologous intrauterine infusion of PRP positively impacts endometrial proliferation and implantation which is safe, low resource and minimally invasive.

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Author Biographies

Sara Mahmood, Salma Kafeel Medical Services, Blue Area, Islamabad, Pakistan

Clinical Embryologist

Salma Kafeel, Salma Kafeel Medical Services, Blue Area, Islamabad, Pakistan

Consultant Gynecologist

Riffat Bibi, Salma Kafeel Medical Services, Blue Area, Islamabad, Pakistan

Clinical Scientist

Naveed Iqbal, Salma Kafeel Medical Services, Blue Area, Islamabad, Pakistan

Consultant Gynecologist

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Published
2019-12-19
How to Cite
1.
Mahmood S, Kafeel S, Bibi R, Iqbal N. Treatment of unexplained thin endometrium with autologous platelet-rich plasma in a frozen embryo transfer cycle. JSTMU [Internet]. 19Dec.2019 [cited 1Dec.2020];2(2):80-2. Available from: https://j.stmu.edu.pk/ojs/index.php/jstmu/article/view/75