Treatment of unexplained thin endometrium with autologous platelet-rich plasma in a frozen embryo transfer cycle

  • Sara Mahmood Salma Kafeel Medical Services, Blue Area, Islamabad, Pakistan
  • Salma Kafeel Salma Kafeel Medical Services, Blue Area, Islamabad, Pakistan
  • Riffat Bibi Salma Kafeel Medical Services, Blue Area, Islamabad, Pakistan
  • Naveed Iqbal Salma Kafeel Medical Services, Blue Area, Islamabad, Pakistan
Keywords: Frozen Embryo Transfer, platelet-rich plasma, thin endometrium, endometrial thickness

Abstract

Inadequate endometrial proliferation is a known cause of implantation failure in assisted reproductive technology cycles. It is generally agreed that >9 mm endometrial thickness is associated with higher implantation. Several strategies have been explored to enhance endometrial proliferation. However, the results are either poor, inconsistent or subject to safety concerns. A 34-year old woman presented with unexplained thin endometrium in successive frozen embryo transfer (FET) cycles. Autologous platelet-rich plasma (PRP) was infused in the uterine cavity on day 10 of second FET cycle enhancing endometrial thickness, which post-PRP infusion measured 10.9 mm. Blastocyst-stage embryos were transferred resulting in a successful pregnancy. Autologous intrauterine infusion of PRP positively impacts endometrial proliferation and implantation which is safe, low resource and minimally invasive.

Downloads

Download data is not yet available.

Author Biographies

Sara Mahmood, Salma Kafeel Medical Services, Blue Area, Islamabad, Pakistan

Clinical Embryologist

Salma Kafeel, Salma Kafeel Medical Services, Blue Area, Islamabad, Pakistan

Consultant Gynecologist

Riffat Bibi, Salma Kafeel Medical Services, Blue Area, Islamabad, Pakistan

Clinical Scientist

Naveed Iqbal, Salma Kafeel Medical Services, Blue Area, Islamabad, Pakistan

Consultant Gynecologist

References

Bos-Mikich A, Ferreira MO, de Oliveira R, Frantz N. Platelet-rich plasma or blood-derived products to improve endometrial receptivity? J Assist Reprod Genet. 2019; 36(4):613-20.

DOI: https://doi.org/10.1007/s10815-018-1386-z

Lebovitz O, Orvieto R. Treating patients with “thin” endometrium–an ongoing challenge. Gynecol Endocrinol. 2014; 30(6):409-414.

DOI: https://doi.org/10.3109/09513590.2014.906571

Gleicher N, Kim A, Michaeli T, Lee HJ, Shohat-Tal A, Lazzaroni E, et al. A pilot cohort study of granulocyte colony-stimulating factor in the treatment of unresponsive thin endometrium resistant to standard therapies. Human Reproduction. 2012; 28(1):172-177.

DOI: https://doi.org/10.1093/humrep/des370

Chang Y, Li J, Chen Y, Wei L, Yang X, Shi Y, et al. Autologous platelet-rich plasma promotes endometrial growth and improves pregnancy outcome during in vitro fertilization. Int J Clin Exp Med. 2015; 8(1):1286-90.

Kunicki M, Lukaszuk K, Liss J, Skowrońska P, Szczyptańska J. Granulocyte colony stimulating factor treatment of resistant thin endometrium in women with frozen-thawed blastocyst transfer. Syst Biol Reprod Med. 2017; 63(1):49-57.

DOI: https://doi.org/10.1080/19396368.2016.1251505

Wright KP, Guibert J, Weitzen S, Davy C, Fauque P, Olivennes F. Artificial versus stimulated cycles for endometrial preparation prior to frozen–thawed embryo transfer. Reprod. Biomed. Online. 2006; 13(3):321-325.

DOI: https://doi.org/10.1016/S1472-6483(10)61434-4

The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Human Reproduction. 2011; 26(6):1270-1283.

DOI: https://doi.org/10.1093/humrep/der037

Aghajanova L, Houshdaran S, Balayan S, Manvelyan E, Irwin JC, Huddleston HG, et al. In vitro evidence that platelet-rich plasma stimulates cellular processes involved in endometrial regeneration. J Assist Reprod Genet. 2018; 35(5):757-770.

DOI: https://doi.org/10.1007/s10815-018-1130-8

Chang Y, Li J, Wei L, Pang J, Chen J, Liang X. Autologous platelet-rich plasma infusion improves clinical pregnancy rate in frozen embryo transfer cycles for women with thin endometrium. Medicine. 2019; 98(3).

DOI: 10.1097/MD.0000000000014062

Farimani M, Poorolajal J, Rabiee S, Bahmanzadeh M. Successful pregnancy and live birth after intrauterine administration of autologous platelet-rich plasma in a woman with recurrent implantation failure: A case report. Int J Reprod Biomed. 2017; 15(12):803-6.

Published
2019-12-19
How to Cite
1.
Mahmood S, Kafeel S, Bibi R, Iqbal N. Treatment of unexplained thin endometrium with autologous platelet-rich plasma in a frozen embryo transfer cycle. JSTMU [Internet]. 19Dec.2019 [cited 8Nov.2024];2(2):80-2. Available from: https://j.stmu.edu.pk/ojs/index.php/jstmu/article/view/75