Vitamin D deficiency: It's contributing factors and prevention
Abstract
Vitamin D deficiency is prevalent across the globe. The most important role of vitamin D is in strengthening the bones. Besides this, vitamin D is likely to be associated with prevention against different types of cancers and chronic diseases like cardiovascular diseases, hypertension, diabetes mellitus and stroke as well as osteoporosis. It also has role in preventing many neurological diseases like depression, chronic fatigue syndrome and neuro-degenerative diseases including Alzheimer’s disease autoimmune diseases, birth defects and periodontal diseases.
Main source of vitamin D is sunlight, also called sunshine vitamin. People with old age, dark skinned and obese cannot produce sufficient amount of Vitamin D. Food sources include fatty fish, animal liver, egg yolk and dairy products, though these are poor sources. Vitamin D deficiency is endemic in Pakistan, India, Sri Lanka as well as Middle Eastern Countries. Though it’s sunny there all the year round, still the bulk of population is vitamin D deficient due to limited sun exposure in extremes of high temperature and socio religious reasons. Similarly, population in Europe and America are also affected. Pregnant mothers and infants are more at risk. Population at risk should be screened and treated. Appropriate health policies, public awareness, and fortification of dairy products can definitely prevent as well as address this huge burden of disease.
Downloads
References
Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr. 2008; 87(4):10805-68. DOI: https://doi.org/10.1093/ajcn/87.4.1080S
Lips P. Vitamin D physiology. Prog Biophys Mol Biol. 2006; 92(1):4-8.
DOI: https://doi.org/10.1016/j.pbiomolbio.2006.02.016
Heldenberg D, Tenenbaum G, Weisman Y. Effect of iron on serum 25-hydroxyvitamin D and 24, 25-dihydroxyvitamin D concentrations. Am J Clin Nutr. 1992; 56(3):533-6.
DOI: https://doi.org/10.1093/ajcn/56.3.533
Boucher BJ. The problems of vitamin d insufficiency in older people. Aging Dis. 2012; 3(4):313.
Aspell N, Laird E, Healy M, Shannon T, Lawlor B, O’Sullivan M. The prevalence and determinants of vitamin D status in community-dwelling older adults: results from the English Longitudinal Study of Ageing (ELSA). Nutrients. 2019; 11(6):1253.
DOI: https://doi.org/10.3390/nu11061253
Shih BB, Farrar MD, Cooke MS, Osman J, Langton AK, Kift R. et. al. Fractional sunburn threshold UVR doses generate equivalent vitamin D and DNA damage in skin types I–VI but with epidermal DNA damage gradient correlated to skin darkness. J Invest Dermatol. 2018; 138(10):2244-52.
DOI: https://doi.org/10.1016/j.jid.2018.04.015
Kandhro F, Dahot MU, Naqvi A, Habib S, Ujjan IU. Study of Vitamin D deficiency and contributing factors in the population of Hyderabad, Pakistan. Pak J Pharm Sci. 2019; 32(3)1063-1068.
Elliott ME, Binkley NC, Carnes M, Zimmerman DR, Petersen K, Knapp K. et. al. Fracture risks for women in long‐term care: high prevalence of calcaneal osteoporosis and hypovitaminosis D. Pharmacotherapy: J Hum Pharm Drug Therapy. 2003; 23(6):702-10.
DOI: https://doi.org/10.1592/phco.23.6.702.32182
Kennel KA, Drake MT, Hurley DL. Vitamin D deficiency in adults: when to test and how to treat. InMayo Clinic Proceedings 2010; 85( 8):752-758.
DOI: https://doi.org/10.4065/mcp.2010.0138
Palacios C, Gonzalez L. Is vitamin D deficiency a major global public health problem? J. Steroid Biochem. Mol. Biol. 2014; 144:138-45.
DOI: https://doi.org/10.1016/j.jsbmb.2013.11.003
Naeem Z, AlMohaimeed A, Sharaf FK, Ismail H, Shaukat F, Inam SB. Vitamin D status among population of Qassim region, Saudi Arabia. Int J Health Sci. 2011; 5(2):116-24.
Jadoon SA, Ahmed A, Alam MA. Vitamin D deficiency in Pakistan: tip of iceberg. J Ayub Med Coll. 2017; 30(1):78-80.
Raza A, Syed JG, Ali FM, Khan MD, Khan MA, Haleem F. et. al. Incidence of Vitamin D Deficiency in Different Seasons in the Adult Karachi Population Presenting in the Medical Outpatient Department with Generalized Body Ache. Cureus. 2019; 11(7):5167.
DOI: https://doiorg/10.7759/cureus.5167
Hunter L, Ferguson R, McDevitt H. Vitamin D deficiency cardiomyopathy in Scotland: a retrospective review of the last decade. Arch Dis Child. 2020.
DOI: http://dx.doi.org/10.1136/archdischild-2019-317794
Bandeira F, Griz L, Dreyer P, Eufrazino C, Bandeira C, Freese E. Vitamin D deficiency: a global perspective. Arq Bras Endocrinol Metab. 2006; 50(4):640-6.
DOI: https://doi.org/10.1590/S0004-27302006000400009
Autier P, Gandini S. Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials. Arch. Intern. Med. 2007;67(16):1730-7.
DOI: https://doi.org/10.1001/archinte.167.16.1730
Bolland MJ, Grey A, Gamble GD, Reid IR. Calcium and vitamin D supplements and health outcomes: a reanalysis of the Women’s Health Initiative (WHI) limited-access data set. Am J Clin Nutr. 2011; 94(4):1144-9.
DOI: https://doi.org/10.3945/ajcn.111.015032
Naeem Z. Vitamin D. Deficiency-An Ignored Epidemic. Int J Health Sci (Qassim). 2010; 4(1).V-VI.
Giustina A, Adler RA, Binkley N, Bouillon R, Ebeling PR, Lazaretti-Castro M. et. al. Controversies in vitamin D: summary statement from an international conference. J Clin Endocrinol Metab. 2019; 104(2):234-40.
Copyright (c) 2019 Journal of Shifa Tameer-e-Millat University
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Journal of Shifa Tameer-e-Millat University (JSTMU) is the owner of all copyright to any work published in the journal. Any material printed in JSTMU may not be reproduced without the permission of the editors or publisher. The Journal accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing and/or decision in this journal. The Editorial Board makes every effort to ensure the accuracy and authenticity of material printed in the journal. However, conclusions and statements expressed are views of the authors and do not necessarily reflect the opinions of the Editorial Board or JSTMU.
Content of this journal is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.